BSc, MSc Biochemistry
Center for Biopharmaceuticals, Department of Drug Design and Pharmacology
Christin received her Bachelor’s and Master’s degrees from the Ruhr-University Bochum, Germany. She conducted her Master’s thesis at Merck, Darmstadt in the department of Biomolecular Analytics, where she established a mass spectrometric-based technique for kinome profile comparison. The application of this technique was focused on small molecule inhibitor characterization to identify potential side effects of cancer drugs. In PDZnet, she will be working on development of D-peptide inhibitors for PSD-95 using mirror image phage display.
BSc Biology & Chemistry, Mres Biological Sciences
Marseille Cancer Research Center (CRCM)
Lukša obtained his Bachelor’s in Biology and Chemistry from University of Split followed by his Master’s in Biological Sciences from University of Manchester. At the University of Manchester, his main research focuses were to examine the effect of extracellular pH on Cinacalcet-induced calcium-sensing receptor activation and the role of the Lowe syndrome protein, inositol polyphosphate 5-phosphatase OCRL-1, in endocytic membrane trafficking. In PDZnet, he will be working on the PDZ-mediated syndecan-phosphoinositide interactions and role of syndecans in trafficking and signaling.
BSc Biology, MSc Biomedicine
Marseille Cancer Research Center (CRCM)
Marta obtained her Bachelor’s in Biology from Universitat Autònoma de Barcelona followed by her Master’s in Biomedicine from University of Barcelona. She worked at the Hospital Clínic in Barcelona, where her main research focus was on HIV. Here, she worked on an EU project testing different drugs to inhibit the HIV nucleocapsid protein. Subseqeuntly, she studied the HIV reservoir. In PDZnet, she will be working on the role of the Vangl1/2 oligomerization and Scribble PDZ-mediated interaction in Vangl2 trafficking to better understand how these interactions are involved in cell migration and breast cancer when Vangl2 and Scribble are deregulated.
MSc Medicinal Chemistry
Department of Medical Biochemistry and Microbiology – BMC
Louise completed her Master’s in Medicinal Chemistry from Aarhus University in collaboration with the University of Copenhagen and University of Oregon. She worked in the field of structural biology exploring the structural framework and function of SERT, TlpA and pnGFP by using radio-labelled binding assays, site directed mutagenesis and crystallography. In PDZnet, she will use the PSD-95 scaffold protein as a model system to explore the significance of the backbone for allosteric network propagation. PSD-95 from different species and predicted ancestors are compared to explore the potential of an evolutionary mechanism for fine-tune of protein-protein interactions through the allosteric network.
Department of Chemistry – BMC
Susanne obtained both her Bachelor’s and Master’s in Biochemistry from University of Copenhagen. During her bachelor’s, she worked on characterizing the interaction between a hub protein and an intrinsically disordered region of a plant transcription factor using isothermal titration calorimetry. In her master’s, she focused on the biological functions of a neural cell adhesion molecule and its ability to induce neurite outgrowth in primary neurons using mammalian cell cultures, co-culture assays, and phosphorylation assays. In PDZnet, she will investigate the plasticity of PDZ domain interactions by using proteomic peptide-phage display to screen for internal binding sites in intrinsically disordered regions of the human proteome.
BSc Biochemistry, MSc Chemical Biology
Department of Biochemical Sciences
Candice obtained her Bachelor’s in Biochemistry from University Claude Bernard Lyon 1, followed by her Master’s in Chemical Biology from Uppsala University. Her Master’s thesis focused on the engineering of aldolases in the Biotransformation and Bioactive Molecules (BBM) research team, iQAC, CSIC, Barcelona, Spain. She was then a research assistant at the International Atomic Energy Agency (IAEA), where her main research focus was on the development of alternative techniques to animal testing. In PDZnet, she will be working on the mechanistic aspects of folding and stability of multidomain PDZ proteins using site-directed mutagenesis and biophysical approaches.
BSc Biochemistry, MSc Bioinformatics
Structural and Computational Biology Research Unit
Jelena Čalyševa obtained her Bachelor’s of Biochemistry from Vilnius University and her Master’s in Bioinformatics degree from Lund University. She did various research projects including her Bachelor’s and Master’s thesis projects in fields of protein science (Vilnius University, Lithuania), DNA and protein sequence analysis and structural bioinformatics (Lund University, Sweden). In PDZnet, she will be developing a bioinformatics method for prediction of internal PDZ-binding sites in proteins.
BSc Human Biology, MSc Bioengineering
Department of Integrated Structural Biology
Pau obtained his bachelor in Human Biology from University Pompeu Fabra and his master in Bioengineering from University Ramon Llull, both in Barcelona. His Master Thesis focused in the behaviour of PimA, a glycosyltransferase protein associated to the membrane in mycobacterium smegmatis, using Molecular Dynamics (MD) approaches. He learned in the process amazing methods related to the exploring of energetic maps of protein folding, between them the Metadynamics. In PDZnet, he will study by large-scale interaction assays the hijacking of PDZ-mediated interaction networks by viral proteins, using bioinformatics to plan and analyse the data.
BSc Food Science, MRes Structural Molecular Biology
Department of Structural Biology & Chemistry; Nuclear Magnetic Resonance of Biomolecules
Yanlei gained his Bachelor’s degrees in Food Science & Engineering and Food Science at Jiangsu University and University of Leeds, respectively, in 2015. Then he pursued his Master’s degree in Structural Molecular Biology at Imperial College London in 2016. Here, he gained experience in the basics of Nuclear Magnetic Resonance (NMR), Molecular Dynamic (MD) simulations and wet lab experimental experience. In PDZnet, he will continue developing his NMR skills by solving the structure of the scaffolding protein, Whirlin, at Institut Pasteur.
Int. M.Sc. Biology
Vivek Kumar Sahoo received his Integrated M.Sc. (Int. M.Sc.) degree in Biology from National Institute of Science Education and Research (NISER), Bhubaneswar, India. In his Master’s project, he worked on elucidating the functional interactions between eIF2β and eIF2γ, where his main research tool was “Molecular Genetics”. He screened eIF2γ suppressors against a known hyper-GTPase mutant eIF2βS264Ywhich would shed more light in understanding the role GTP hydrolysis in Eukaryotic translation initiation. In PDZnet, he will be studying the impact of PDZ domain containing proteins and PDZ binders on synaptic/neuronal activity using pathSCREENER and cisPROFILLER assays.
B.Sc., M.Sc. Chemistry
Department of Peptide and Protein Chemistry
Dominik obtained his Bachelor’s and Master’s degrees in Chemistry from the University of Stuttgart and the Technical University of Munich, respectively. His Master´s thesis studies were focused on the light-dependent conformational switching of the Caseinolytic protease P (ClpP) through incorporation of unnatural amino acids by a genetic code expansion approach. Subsequently, he joined the Innovations department of Insilico Biotechnology AG for an internship in the field of bioinformatics. In PDZ, he will elucidate the dynamic regulation of PSD-95 by phosphorylation and thereof, identify novel potential therapeutic targets.
BSc Chemistry, MSc Drug Research & Development
Department of Peptide and Protein Chemistry
Javier obtained his Bachelor’s in Chemistry and Master’s in Drug Research and Development from Barcelona University. He was a Junior Researcher at the Consejo Superior de Investigaciones Científicas, where his main research focus was on therapeutical applications of peptides and microarray technology. He developed a peptide microarray system to identify human biomarkers for the GBV-C. In PDZnet, he will apply the peptide SPOT array technology to examine the underexplored PDZ internal interactome.
The PDZnet network includes 11 academic research groups and 3 industrial partners distributed across 6 European countries (Denmark, France, Germany, Italy, Portugal, and Sweden). The network provides an international and multidisciplinary PhD training platform for 14 next-generation researchers (PhD students).
We train PhD fellows to become independent, creative and innovative scientist by providing cutting-edge knowledge, a diverse and comprehensive technology platform, and transferable skills training making the young researchers attractive candidates for research positions in academia or industry.